By Alex Avdeef
Explains easy methods to practice and study the result of the most recent physicochemical methods
With this e-book as their consultant, readers have entry to all of the present info had to completely examine and correctly confirm a compound's pharmaceutical homes and their results on drug absorption. The e-book emphasizes oral absorption, explaining all of the physicochemical equipment used this day to research drug applicants. additionally, the writer offers professional suggestions to aid readers study the result of their stories so one can decide upon the main promising drug candidates.
This Second Edition has been completely up to date and revised, incorporating all of the most recent learn findings, equipment, and assets, including:
Descriptions and purposes of latest PAMPA versions, drawing on greater than thirty papers released by way of the author's examine group
Two new chapters reading permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded info and strategies to help pKa determination
New examples explaining the therapy of virtually insoluble attempt compounds
Additional case stories demonstrating using the newest physicochemical techniques
New, revised, and improved database tables during the book
Well over 2 hundred drawings aid readers greater comprehend tricky strategies and supply a visible advisor to complicated methods. furthermore, over 800 references function a gateway to the first literature within the box, facilitating extra learn into all of the issues coated within the book.
This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar components of study. it's also instructed as a supplemental textual content for graduate classes in pharmaceutics.
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Extra resources for Absorption and Drug Development: Solubility, Permeability, and Charge State
Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef